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Cybersecurity & Infrastructure Security Agency
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Appendix A: Chemicals of Interest

Keeping hazardous chemicals out of the hands of those who would misuse them is a responsibility shared between facility owners and operators, employees, and emergency responders and the Cybersecurity and Infrastructure Security Agency (CISA).

Appendix A of the Chemical Facility Anti-Terrorism Standards (CFATS) regulation (6 CFR Part 27) lists more than 300 chemicals of interest (COI) and their respective screening threshold quantities (STQ) and concentrations. These COI are categorized under three main security issues:

  • Release: Toxic, flammable, or explosive chemicals or materials that can be released at a facility.
  • Theft or Diversion: Chemicals or materials that, if stolen or diverted, can be converted into weapons using simple chemistry, equipment, or techniques.
  • Sabotage: Chemicals or materials that can be mixed with readily available materials.

First Step: Read the Appendix A CFATS Chemicals of Interest (COI) List if your facility possesses or plans to possess any chemical(s). Any COI that meets or exceeds the STQ and concentration must be reported to CISA.

Facilities that Possess COI

A facility that meets or exceeds the specified concentrations and quantities for any COI is required to report possession of those chemicals to CISA by completing an online survey called a Top-Screen via the Chemical Security Assessment Tool (CSAT).

CISA reviews Top-Screens using a risk-based methodology. Facilities are notified once they are either:

  • Determined to be a high-risk facility, and ranked into Tier 1, 2, 3, or 4, with Tier 1 being the highest risk.
  • Determined to not be a high-risk facility and not regulated under CFATS.

Facilities determined to be "high-risk" are required to develop a security plan and implement security measures that reduce the risks associated with their COI.

COI Resources for Facilities

CISA regularly engages with stakeholders to identify how to reach new segments of the population and ensure that those who hold COI are aware of their obligation to report.

Please download, print, and distribute these voluntary resources to increase the awareness of the CFATS program.

Chemical Facility Anti-Terrorism Standards (CFATS) Ammonia Flyer

PUBLICATION
This flyer is a resource to ensure facilities are aware that ammonia (anhydrous) is a chemical of interest (COI) under the Chemical Facility Anti-Terrorism Standards (CFATS) program.
Download File (PDF, 257.04 KB)

Chemical Facility Anti-Terrorism Standards (CFATS) Ammonium Nitrate Flyer

PUBLICATION
This flyer is a resource to ensure facilities are aware that ammonium nitrate—Chemical Abstracts Service Number (CAS #) 6484-52-2—is a chemical of interest (COI) under the Chemical Facility Anti-Terrorism Standards (CFATS) regulation.
Download File (PDF, 488.7 KB)

Chemical Facility Anti-Terrorism Standards (CFATS) Hydrogen Peroxide Flyer

PUBLICATION
This flyer is a resource to ensure facilities are aware that hydrogen peroxide at a concentration of 35 percent or higher is a chemical of interest (COI) under the Chemical Facility Anti-Terrorism Standards (CFATS) program.
Download File (PDF, 280.4 KB)

Chemical Facility Anti-Terrorism Standards (CFATS) Nitromethane Flyer

PUBLICATION
This flyer is a resource to ensure that facilities are aware that nitromethane is a chemical of interest (COI) under the Chemical Facility Anti-Terrorism Standards (CFATS) program.
Download File (PDF, 291.63 KB)

Chemical Facility Anti-Terrorism Standards (CFATS) Propane Flyer

PUBLICATION
This printer-friendly flyer is a resource to ensure facilities are aware that propane is a chemical of interest (COI) under the Chemical Facility Anti-Terrorism Standards (CFATS) program.
Download File (PDF, 250.28 KB)

Chemical Facility Anti-Terrorism Standards (CFATS) Receiving a Chemical of Interest (COI) Flyer

PUBLICATION
This flyer can be used as a voluntary tool by facilities when shipping, selling, or distributing a Chemical Facility Anti-Terrorism Standards (CFATS) chemical of interest (COI) to notify customers that they may need to report their chemical holdings to CISA.
Download File (PDF, 287.96 KB)

Chemical Facility Anti-Terrorism Standards: Most Commonly Regulated Chemicals of Interest

PUBLICATION
Any facility that possesses or plans to possess any of the chemicals of interest (COI) regulated under the Chemical Facility Anti-Terrorism Standards (CFATS) regulation at or above a specified quantity or concentration must report their holdings to CISA.
Download File (PDF, 876.88 KB)

Appendix A Final Rule

On November 20, 2007, the Department published the Final Rule for the Appendix A in the Federal Register making all provisions of 6 CFR Part 27, including § 27.210(a)(1)(i), operative and in effect.

In developing Appendix A, the Department referenced existing expert sources of information including other federal regulations related to chemicals, such as:

  • Chemicals covered under the Environmental Protection Agency's Risk Management Program
  • Chemicals included in the Chemical Weapons Convention
  • Hazardous materials, such as gases that are poisonous by inhalation
  • Explosives regulated by the Department of Transportation

CISA continues to assess available information about chemicals critical to the government mission and the economy. The Agency will use the information it collects through the Top-Screen process to identify facilities responsible for economically critical and mission-critical chemicals.

Contact

For more information about the CFATS program, please contact CFATS@hq.dhs.gov.

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